Blinded By Reye’s
Although aspirin generally comes with a warning against its use by children – due largely to an historical association with Reye’s Syndrome – there is much evidence suggesting a very different story.
According to one study from a Florida paediatric hospital, Reye’s Syndrome(RS) was a ‘rare disease which…disappeared…in the late 1980s. An association between Reye’s syndrome and the ingestion of aspirin was claimed, although no proof of causation was ever established.’
The study went on to state that the presence of aspirin has not been shown to be in the blood of RS patients and that ‘no animal model of Reye’s syndrome has been developed where aspirin causes the disease’.
Other studies have shown a far greater correlation between RS and paracetamol (acetaminophen) use, and epidemiological evidence seems to show that the disease was in significant decline long before warnings against aspirin use began.
“The diagnosis of Reye’s syndrome was confirmed pathologically in 42 of 49 cases (86%). Aspirin or salicylate ingestion occurred in only 4 (8%), and paracetamol (acetaminophen) ingestion in 12 (24%)…”
Aspirin has long been used as a preventative measure for children at risk of stroke, or a high risk of embolism due to congenital or acquired cardiac disease, and it appears that there are ‘no published examples of children who developed Reye’s syndrome while taking prophylactic aspirin.’
The 1980s campaign warning against aspirin use by children appears to have coincided with a dramatic increase in the sale of newer more profitable drugs like Tylenol or Panadol.
There is, however, evidence showing increased levels of polyunsaturated fats in the blood of children with Reye’s Syndrome, suggesting the possibility that aspirin therapy (being highly protective against the inflammatory breakdown products of the polyunsaturated fats) would be an effective and reasonable approach to treatment.
“Serial measurements of total serum free fatty acids (FFA) showed that levels were increased during RS and, after recovery, were significantly lower in the patients who survived…The increase in polyunsaturated fatty acids in FFA, the precursors of prostaglandins, suggests that a grossly disturbed prostaglandin pattern may occur in RS.”
For these and other reasons, a diet restricting the intake of the polyunsaturated fats, and providing sufficient protein, sugar and other nutrients (from sweet ripe fruits, fruit juice, milk, cheese, honey, white sugar and some well cooked starchy vegetables like white potatoes) – in order to help avoid exposure to excessive levels of free fatty acids – would appear to be a logical and rational approach to optimizing health and preventing disease, including Reye’s.
Have you seen any science effectively showing a causative relationship between aspirin use and the onset of RS?
See more here.
Is aspirin a cause of Reye’s syndrome? A case against.