Prepare To Be Salt Struck

ASalt One good way of looking at salt, is to see it as an all purpose, metabolism enhancing, stress reducing, anti-inflammatory, disease protective, anxiolytic, anti-depressant. Now that was a mouthful, wasn’t it?

As a general rule, when dietary sodium is restricted, thyroid energy metabolism is interfered with. Another way of saying this is that insufficient salt intake, tends to promote a variety of biochemical changes, that can increase stress, promote inflammation, and encourage thyroid metabolism dysfunction, causing all sorts of disease symptoms.

Although it isn’t easy to find all of this information in one place, it is possible to put together a good case for the metabolically protective, stress lowering effects, of increasing salt consumption, by consolidating a number of biologically related pieces of the puzzle.

For starters, salt restriction alone, has been demonstrated to increase stress, for instance by increasing levels of the catecholamines, such as adrenaline and noradrenaline. Excessive exposure to stress, is something that is well known to interfere with metabolic function.

It’s important to understand, that an overly stressed, suppressed metabolism, shifts away from the efficient use of sugar, towards the increased release of fat from storage, as an alternative source of fuel.

Rising exposure to free fatty acids, in particular when they are increasingly polyunsaturated (PUFAs) in composition, is well known to cause inflammation, and in many different ways, to further promote stress and suppress thyroid function.

This kind of high stress scenario, can itself promote a greater loss of sodium, and is also associated with an additional rise in the release of the stress substances, including adrenaline. This can potentially create a vicious circle of stress.

When thyroid energy metabolism is under functioning, digestion tends to be impaired, which then allows for bacteria to feed and grow in number, and for greater absorption of bacterial toxins, like endotoxin, to enter into the blood stream. Digestive health and mental health are closely tied to each other, in both directions.

Bacterial endotoxin is directly inflammatory, and causes an increase in serotonin levels, and both of these stress substances, interfere with energy metabolism, and have been shown to increase symptoms of stress, anxiety and depression.

The more the thyroid system is interfered with, the more the stress system goes into action, and this means more adrenaline. More exposure to adrenaline and other mediators of stress, interferes with sleep, increases anxiety levels, and promotes many of the stress related diseases of inflammation. Improving sleep is important for healing, and this includes mood regulation issues in general.

Simply increasing salt intake is something which is known to be able to help prevent or reduce metabolic stress, and protect against inflammatory illness, in a multitude of ways.

Sufficient salt consumption can suppress adrenaline, raise body temperature, and improve sleep quality. Increasing body temperature, has alone been shown to be able to treat chronic and serious depression. More sodium can also help improve digestion, and this can result in the reduction of bacterial endotoxin exposure, thereby lowering secretion of serotonin and many other inflammatory stress related things that also cause metabolic issues and mood disorders.

Low serum sodium is connected with high HDL (the so called ‘good cholesterol’), which contrary to popular opinion, has been shown to rise in response to endotoxin exposure and excessive stress in general, and which rather than being an indicator of improved health, is actually associated with increased mortality.

It makes sense that increasing salt intake, by improving metabolism and lowering stress in general, can also improve overall cholesterol regulation, including helping with conversion of cholesterol into the protective steroid hormones, such as testosterone and progesterone.

Hyponatremia or low levels of sodium in the blood, activates the renin‐angiotensin‐aldosterone system (RAAS), and chronic activation of the RAAS, can be responsible for congestive heart failure, systemic hypertension, and chronic kidney disease.

Excessive exposure to angiotensin II and aldosterone promotes fibrosis, and the inflammatory milieu responsible for remodeling cardiovascular tissue seen in heart disease. A low sodium diet has been shown to cause aortic damage and to increase heart rate, even with reduced blood pressure.

Insufficient salt intake and the activation of the renin‐angiotensin‐aldosterone system (RAAS), interferes with blood sugar regulation, and promotes insulin resistance. Inhibition of this system by increasing salt intake, can improve blood sugar regulation and reduce the incidence of diabetes, as well as mortality from cardiovascular disease. Blood sugar issues, heart disease, suppressed thyroid, and depression and anxiety, often go together for metabolically explainable reasons.

Both diabetes and cardiovascular disease have been shown to be connected to high stress, inflammation, and thyroid issues, including exposure to increased amounts of endotoxin and PUFAs. In patients with type 2 diabetes, lower urinary sodium excretion has been associated with increased all-cause mortality, and the highest mortality risks were observed in patients with the lowest sodium intake.

Apart from being able to promote hypertension, thyroid dysfunction has also been shown to be a cause of hyponatremia, and limiting water intake and increasing sodium, is known to be able to be an effective treatment for this, as well as even for cases of severe hyponatremia with epileptiform seizures.

Hyponatremia is able to cause sudden onset dementia, which again has been reversed by increasing serum sodium. It is probably no coincidence, that Alzheimer’s has also been shown to be an inflammatory disease, that is closely associated with hypo-metabolism and the substances of stress, including exposure to endotoxin and the breakdown products of the PUFAs. Again, dementia and mood dysregulation are closely tied together.

Stress and hypothyroidism is connected with iron dysregulation, and the relationship between inflammation, endotoxin exposure, iron excess, and dementia, is practically undeniable. Insufficient salt consumption is very likely to be an exacerbating factor.

Serum sodium levels in hyponatremia, are inversely correlated with many markers of inflammatory disease, including C-reactive protein and the inflammatory cytokines serum IL-6 and IL-1β, and it has been hypothesized that hyponatremia may be associated with inflammatory diseases in general.

Reduced serum sodium levels have also been inversely correlated with increased prostaglandin levels, involved in worsening congestive heart failure. In fact, reduced blood levels of sodium are considered a risk factor for mortality in critically ill patients, and there are many cases of hospital patients dying as a result of being given plain water, without first checking for hyponatremia.

Rather than being responsible for high blood pressure, sufficient salt intake can be something which helps to reduce hypertension, often resulting from stress and hypothyroidism issues, including the excessive release of adrenaline, cortisol, serotonin, and a number of related factors. Lack of salt can also cause a rise in cortisol and serotonin levels, and SSRI ‘anti-depressants’, which are intended to increase serotonin levels, have been shown to be able to cause hyponatremia and serotonin syndrome simultaneously, both of which are potentially life threatening. Not surprisingly, SSRIs have also been associated with worsening depression, anxiety and increased suicide.

Also related to this, over-activity of the HPA axis and high cortisol, seem to go together with significantly increased aldosterone levels in cases of depression. As mentioned earlier, aldosterone is known to rise as a result of sodium restriction.

Nitric oxide is another thing which rises during stress and when digestion and metabolism is suppressed, and excessive exposure has been found to be able to promote hypertension. Increased salt consumption has been shown to lower nitric oxide (which may be responsible for the temporary blood pressure lowering effects of salt restriction), and nitric oxide powerfully suppresses energy metabolism. This is another important factor driving inflammatory illness, including depression, anxiety and cancer.

There is a powerful connection between metabolic function, and the relationship between sodium and the other alkaline minerals, magnesium, potassium and calcium. The hypothyroid state is closely linked to the biological interactions between these minerals, and they have all been shown to play a part in mood instability issues.

One of the early things that happens when stress is high and thyroid energy metabolism is under functioning (when oxygen or glucose availability is interfered with, and ATP production is impeded), is that there is an impact upon proper sodium regulation in the body. This impacts upon alkaline mineral homeostasis in general, which can then go on to have stress increasing consequences. Providing enough sugar, and avoiding the stress promoting and inflammatory PUFAs is one way to help keep the minerals in balance.

High serum lactate levels, are another good indicator of stress and suppressed metabolic function, and in combination with low serum sodium levels, have been shown to be a significant predictor of mortality in necrotizing soft-tissue infections (NSTI), often involving sepsis and multisystem organ failure. Increased lactic acid (often combined with increased bacterial endotoxin exposure), is another driver of mood related issues, including anxiety and panic attacks.

Extra intake of salt can go a long way towards improving the regulation of all the alkaline minerals, protecting against deficiencies in (and preventing excessive wastage of) any of them, helping to guard against mood dysregulation and inflammatory illness in general. Sufficient intake of calcium and magnesium and potassium is still very important however, and many metabolic issues, including mood issues, can be prevented or reduced with an increased and balanced intake, from the right sources.

In any case, it appears that enough salt consumption is a very important factor, and it has been observed that loss of calcium and magnesium can be increased with sodium restriction, and insufficient sodium intake can continue to interfere with calcium and magnesium levels, even when calcium and magnesium intake is sufficient.

On the other hand, increasing magnesium has been shown to cure depression in a number of ‘treatment resistant’ cases, and hypertension has been proven to very often be the result of insufficient calcium intake.

Regardless, a large number of studies have shown that symptoms of depression and anxiety rise when metabolism is damaged in numerous different ways, and when the various stress substances (such as cortisol, nitric oxide, estrogen and serotonin) are increased because of the impact of the low energy or hypo-metabolic state.

Estrogen excess is closely associated with thyroid dysfunction and inflammation, as well as mood dysregulation, and it makes sense to see salt as an anti-estrogen substance in many ways, includung via protection against the inflammatory stress substances like bacterial endotoxin, via promotion of the anti-estrogen hormones, and simply via the up-regulation of energy system function in general.

I’m not a doctor or a nutritionist, but from what I have seen, it appears that adequate intake of salt, and the other important minerals, can help protect against metabolic dysfunction, and shift the body away from chronic sympathetic nervous system over-activity. Salt seems to also help protect against many of the inflammatory conditions (including diabetes, cancer and heart disease), which are all known to develop and worsen, because of damage to energy production systems, and excessive exposure to the defensive stress substances that play a big part in harming metabolism in the first place.

The combination of gradually increased consumption of simple sugar and salt (in the context of an appropriate anti-inflammatory, pro-metabolic diet and lifestyle) can be one of the significant things, that can lead to vast improvements in the biochemical, hormonal and nervous system related issues, which underlie the progression of many kinds of chronic diseases, or disturbances of the mind.

A diet with enough protein and other nutrients from milk, cheese and gelatinous meats, as well as plenty of sugar from sweet ripe fruits, fruit juice, honey and white sugar, has been shown to be a biologically reasonable approach to improving anxiety or depression and related inflammatory issues. Experimenting with gradually increasing salt intake (some say starting at 5 grams spread over the day), can potentially be the missing link to lowering stress and getting energy metabolism to start working again.

Salt cravings, as with sugar cravings, are very common, and can be one way to determine how much is needed at a particular time, however it is also possible that salt cravings can increase to compensate for other deficiencies, or because of increased stress in general. It’s important to be aware of the fact that metabolic issues can be complicated, and that blindly following one approach, without being aware of other possibilities, and without noticing changing symptoms and metabolic indicators, can be problematic. This is especially true in more serious circumstances, when metabolism is severely impeded. Keep in mind however, that much like with sugar, so called ‘high salt diets’ are very often high in problematic ingredients, like the PUFAs, that can be responsible for issues related to sodium homeostasis, many times incorrectly blamed on salt consumption.

A salty sugary drink, like for instance milk or orange juice with a few pinches of salt, and added sugar or honey, can, when taken during the day and before bed (or even when awakening during the night), help to improve sleep quality, which in and of itself, will likely alleviate many issues of stress and inflammation, which can have a powerful effect on mood states, and resilience to stressful life circumstances.

Have you experimented with increasing your salt intake?

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Image: Rakkard: “A salt with a deadly weapon”

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