The Cholesterol Hypothesis’ Epic Fail

Medicame This 2015 Japanese study had a few things to say about high cholesterol and cholesterol lowering drugs.

“Cholesterol is a negative risk factor for all-cause mortality…mortality actually goes down with higher total or low density lipoprotein (LDL) cholesterol levels”

“The theory that the lower the cholesterol levels are, the better is completely wrong in the case of Japan, in fact, the exact opposite is true.”

“Elderly people with high cholesterol levels live longer irrespective of where they live”

“One of the biggest contributors to the inverse correlation between the lowest cholesterol levels and the highest all-cause mortality is cancer mortality”

“Liver disease seems to show the most marked association with cholesterol. Liver cancer incidence, liver cirrhosis mortality, and liver disease mortality have been found to be null in subjects with the highest cholesterol levels”

“Low cholesterol levels constitute a risk factor for stroke mortality, while mid to high cholesterol levels constitute a low risk”

“Physicians don’t have enough time to study the cholesterol issue by themselves, leaving them simply to accept the information provided by the pharmaceutical industry”

“There is accumulating evidence for the carcinogenicity of statins….while statins lower cholesterol levels, they do not prevent CHD disease…Unfortunately…many…doctors try to reduce patients’ cholesterol levels without due consideration of these overall findings.”

The study also discusses the relationship between statin drugs and nervous system disorders (including peripheral neuropathy, diminished sexual pleasure and memory impairment), serious birth defects, musculoskeletal disorders, as well as serious liver dysfunction.

“…Are statins actually effective for preventing coronary heart disease in type 2 diabetes mellitus….the answer is unfortunately ‘No’…In fact, statins deteriorate glucose metabolism and increase…diabetes”

“…The biggest mistake made by medical science in the previous century….the cholesterol hypothesis relies on very weak data—and sometimes considerably distorted data….cholesterol plays a very positive role in health.”

“We believe the answer is very simple: for the side defending this so-called cholesterol theory, the amount of money at stake is too much to lose the fight”

From a biological perspective, cholesterol – alongside glucose – plays a fundamental role in the protection against stress of any kind, as well as disease in general.

Whenever any reasonably healthy person is exposed to stress, cholesterol – which happens to be the precursor to the protective ‘anti-stress’ steroid hormones (pregnenolone, progesterone, and DHEA) – rises defensively.

Inhibiting the body’s ability to produce and supply cholesterol – via the use of statin drugs or other artificial cholesterol lowering substances (for example, the polyunsaturated fats) – is far from being safe, and will directly interfere with the most basic physiological protections against degeneration and disease.

The only way to safely keep cholesterol levels from consistently being ‘too high’, is via an improvement in overall metabolic function, thereby increasing production of the protective anti-cancer hormones, particularly progesterone.

Sugar is crucial for both the production of cholesterol, and for the effective conversion of cholesterol into the protective, anti-aging hormones.

Is your doctor aware of the biological significance of cholesterol, and its role in the defence against stress and the onset of disease?

Annals of Nutrition & Metabolism 2015;66(suppl 4):1–116


Image: David Hammerstein
“¿Oscurantismo o acceso abierto a los datos sobre los medicamentos?”

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