Feeling Very Periactin

Cypro When a drug has been around for many decades, tried and tested, with very few known ‘side-effects’, yet helpful with a long list of conditions, there’s a good chance you won’t be hearing about it from your doctor.

This becomes doubly true, when that same drug – cyproheptadine (Periactin) on this occasion – happens to be recognizably anti-serotonergic in effect.

Periactin has been used over the years to treat many chronic and potentially serious metabolic problems. It’s a long list, and it includes insomnia and various other sleep related issues; depression and anxiety as well as schizophrenia; migraines and cluster headaches; digestive issues; skin disorders; addiction; autism; even cancer.

So what is it then, that makes the medical world appear as though it is largely oblivious to such a cheap and simple, first generation anti-histamine, and it’s multitude of beneficial effects.

The story becomes a little clearer, when looking at a biologically more generalized picture of some of the interrelationships between histamine, and serotonin, as well as many other inflammatory by-products of chronic stress or any kind of interference with thyroid and energy metabolism.

One logical way of viewing ‘cypro’ (a moniker often lovingly used by it’s supporters) is to see it as an anti-estrogen, pro-thyroid substance.

The inflammatory substances, serotonin, histamine and estrogen are physiologically related, and in a variety of different ways, have a powerful tendency to promote each others secretion and activity.

Under conditions of stress, and when thyroid function is sub-optimal, many factors can combine to further promote a vicious cycle type effect involving the above degenerative substances.

When energy systems are interfered with, the resulting increased release of the polyunsaturated free fatty acids, as well as the subsequent slowing of digestive processes and rise in bacterial endotoxin levels, only adds momentum to this inflammation creating scenario. This becomes especially true if sugar, or fuel generally, is being restricted.

By potentially lowering endotoxin, serotonin and cortisol, and possibly even preventing the synthesis from free fatty acids, of the inflammation creating prostaglandins, cypro can, amongst other things, help to take strain off the liver, allowing it to do the important job of further removing toxic metabolism interfering substances, not the least of which is estrogen, and encourage thyroid and mitochondrial energy systems to start to function more effectively.

These improvements, as well as many others that often go hand in hand, can go a long way towards creating the possibility of a change in direction away from spiraling degeneration, and general ill health in its many potential incarnations, towards a state of improving metabolic function leading to healing and recovery.

So in one sense, if it were to become widely accepted and promoted, that reducing serotonin and estrogen, can be a component of a metabolism enhancing and general disease protective strategy, and that this could in part be achieved with the use of a very cheap, highly available and no longer patentable, anti-histamine, then it’s possible that some new dilemmas might arise.

For starters, this has the potential to interfere with the sale of a number of the most profitable drugs in pharmaceutical industry history, in particular the serotonin promoting, so called anti-depressants, and many estrogen related products.

Probably even more threatening than that, however, is the way in which a biologically rational approach such as this, contradicts, and undermines a very large portion of what can be considered the ‘officially accepted’ prevention and treatment methodologies, most commonly recommended for many medical and other health related issues.

Although cypro doesn’t appear to have the liver toxic effects that some of the non first generation anti-histamine’s have been shown to have, and is generally very well tolerated, there are some who react less optimally.

For those people, as well as anybody preferring not to use a drug, the beneficial effects of cypro can be safely replicated in many ways, via dietary means.

Unfortunately, once again, however, many reasonable and experimentally demonstrable nutritional approaches to thyroid dysfunction and general disease protection, go against the vast majority of popularly held belief systems most often provided today, in the form of dietary advice. This is especially true in relation to what has become the overwhelmingly popular and increasingly dogmatic anti-sugar rhetoric of the day.

In any case, from a biological perspective, one of the safest approaches to serotonin and estrogen reduction, is via dietary and other lifestyle changes which can promote metabolism and thyroid function.

Sufficient intake of sugar can play a big part in this. By its ability to suppress cortisol, as well as by slowing the release of the polyunsaturated free fatty acids, as alternative fuel under conditions of stress, sugar not only helps to reduce inflammation and promote thyroid activity and digestive function, it also prevents the excessive catabolization of valuable tissue, thus reducing the amount of circulating tryptophan (mobilized from the breakdown of muscle) available for conversion into serotonin.

A diet avoiding the polyunsaturated fats, and restricting intake of tryptophan from muscle meat and other dietary sources, and also providing enough protein from milk, cheese and gelatin, and sufficient sugar from sweet ripe juicy fruits, fruit juice, honey and white sugar, can help to improve digestion, and liver function and eventually help to promote a healthy thyroid metabolism, protecting against many of the systemically damaging effects of excess serotonin, estrogen, histamine and numerous other inflammatory substances.

So you can see, in some ways, how a product like Periactin, when understood in this light, goes against many of today’s influential belief systems and highly protected organizations and institutions.  The safest approach, for some, might be to simply ignore it’s existence, and continue advocating a serotonin raising philosophy.

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Anti-endotoxic shock effects of cyproheptadine in rats.

Modification of adrenal function by the anti-serotonin agent cyproheptadine.

Effect of cyproheptadine on the spontaneous diurnal variations of plasma ACTH-cortisol and ACTH-GH secretion induced by l-dopa.

Effect of the antiserotonin drug, cyproheptadine, on plasma beta-endorphin and beta-lipotropin in patients with Itsenko-Cushing’s disease.

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Unexpected remission of hepatocellular carcinoma (HCC) with lung metastasis to the combination therapy of thalidomide and cyproheptadine: report of two cases and a preliminary HCC cell line study.

The anti-histaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor

Cyproheptadine in the treatment of autistic disorder: a double-blind placebo-controlled trial.

A pharmacological network for lifespan extension in Caenorhabditis elegans

Treatment of the serotonin syndrome with cyproheptadine.

Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c

Cyproheptadine for prevention of neuropsychiatric adverse effects of efavirenz: a randomized clinical trial.

Cyproheptadine in treatment of chronic schizophrenia: a double-blind, placebo-controlled study.

Cyproheptadine: A Potentially Effective Treatment for Functional Gastrointestinal Disorders in Children.

Cyproheptadine displays preclinical activity in myeloma and leukemia.

Inhibition of Hypoglycemia-Induced Cortisol Secretion by the Serotonin Antagonist Cyproheptadine

Cyproheptadine Use in Children With Functional Gastrointestinal Disorders.

Cyproheptadine significantly improves the overall and progression-free survival of sorafenib-treated advanced HCC patients

Treatment of primary erythromelalgia with cyproheptadine.

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.

Cortisol responses to emotional stress in men: Association with a functional polymorphism in the 5HTR2C Gene

Cyproheptadine use in hepatocellular carcinoma

Inhibitory effects of antihistamines and antiserotonins on the bone marrow reactions produced by Escherichia coli endotoxin in mice.

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways.

Cyproheptadine in the management of the galactorrhea-amenorrhea syndrome.

[Anti-inflammatory effect of cyproheptadine].

Cortisol responses to emotional stress in men: Association with a functional polymorphism in the 5HTR2C Gene

Use of cyproheptadine in young children with feeding difficulties and poor growth in a pediatric feeding program.

Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia.

Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase

Cyproheptadine is an effective appetite stimulant in cystic fibrosis.

Effects of cyproheptadine on TXB2 and 6-keto-PGF1 alpha plasma levels in rabbits with hemorrhagic shock.

Cyproheptadine for the treatment of functional abdominal pain in childhood: a double-blinded randomized placebo-controlled trial.

Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

Cyproheptadine in treatment of chronic schizophrenia: a double-blind, placebo-controlled study.

[Protective effects of cyproheptadine on calcium paradox in isolated rat hearts].

Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine

Carcinoid myopathy and treatment with cyproheptadine (Periactin)

Effect of cyproheptadine hydrochloride on spermatogenesis.

Further Studies of Cyproheptadine As An Antiallergic, Antipruritic Agent

Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats.

The use of antiserotonin-cyproheptadine HCL in pregnancy: an experimental and clinical study.

Improved oral glucose tolerance following antiserotonin treatment in patients with chemical diabetes.

Carbohydrate Metabolism and Survival of Endotoxin-Poisoned Mice Given Tryptophan

The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.

Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.

Calotropis procera Latex-Induced Inflammatory Hyperalgesia—Effect of Antiinflammatory Drugs

Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study.


Image: Super Apeti Reviews: Rarely Used Treatment For Allergies





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