The Fantastic Fitness Fiasco

The word exercise has become so loaded, that you can’t really use it anymore without encouraging behavior which ends up being anything but healthy. Combine that with restrictive dietary protocols popular today, and what you have is a potential time bomb.

People vary in terms of their resilience and overall metabolic condition, and what may be beneficial for one has potential to cause harm to another. As you move beyond your capacity to provide energy under stress, ‘exercise’ – which under different circumstances might have lead to a positive adaptive response – can become harmful.

“Exercise elicits an immunological “danger” type of stress and inflammatory response that, on occasion, becomes dysregulated and detrimental to health. Examples include anaphylaxis, exercise-induced asthma, overuse syndromes, and exacerbation of intercurrent illnesses.”

Today’s environments are filled with an increased variety of stress promoters, some completely new to existence. Far higher quantities of polyunsaturated fats (PUFAs) and other damaging ‘foods’; different kinds of radiation; toxic chemicals in the water; plastics and heavy metals; smog; dangerous medicines and supplements; the list goes on.

Unfriendly Environments

Exposure to stress adds up – its effects build up in your system – which means that by the time it comes to ‘getting fit’, many are already chronically stressed, and are far more susceptible to damage from ‘too much’ or the ‘wrong’ kind of exercise.

“This study provides further evidence that the acute phase response consequent to exercise is analogous to that which occurs in general medical and surgical conditions.”

But it isn’t just the external environment that can be dangerous and inflammatory. Stress directly interferes with digestive function, impedes intestinal barrier capability and allows bacterial toxins (such as endotoxin and other stress related substances), to pass through into the main system.

“Prolonged physical exertion…has…been shown to disturb intestinal…integrity, resulting in increased…per­meability, endotoxin leakage, and a subsequent cytokine-mediated systemic inflammatory response similar to that of an acute infectious episode.”

The risks associated with exercise depend a lot on the type of activity, the manner in which it is performed, and how long it goes for. Other factors playing a part include weather or air quality, a person’s metabolic condition, their diet, and how they refuel before and after.

“Gastrointestinal (GI) complaints are common among athletes with rates in the range of 30% to 70%. Both the intensity of sport and the type of sporting activity have been shown to be contributing factors…gastroesophageal reflux disease (GERD), nausea, vomiting, gastritis, peptic ulcers, GI bleeding, or exercise-related transient abdominal pain (ETAP) may develop.”

Stress, PUFAs and Aging

Modern dietary protocols suggest sugar restriction and PUFAs (as well as other problematic things) – and generally push foods that do not provide sufficient bio-available protein (and other nutrition), or enough caloric density – promoting bacterial growth and blood sugar issues, which can multiply the metabolically interfering effects of stressful exercise.

As a person ages and more PUFAs are stored in tissue, susceptibility to the potential dangers of exercise increases. Bacterial toxins promote a rise in levels of the stress substances (such as nitric oxide, serotonin and estrogen), and when glycogen levels run low – both from the strain of exercise and the restriction of sugar – cortisol and adrenaline rise, and the polyunsaturated free fatty acids increase in circulation.

“Strenuous physical performance…significantly reduces blood flow to the gut, leading to…gastrointestinal (GI) compromise….abdominal distress and impairments in the uptake of fluid, electrolytes, and nutrients…loss of epithelial integrity…increased intestinal permeability with bacterial translocation and inflammation.”

“After 4 weeks of exercise, there were significant increases in cortisol, free testosterone levels, and [lactate] activity along with a significant decrease in the ratios between testosterone and cortisol levels.”

If metabolism is further suppressed because of continuous exposure to stressful exercise, toxic substances can pass through into the main system and overload the liver, preventing proper detoxification, and causing interference with other organ systems.

As rising levels of stress substances interact with circulating PUFAs, inflammation can turn into a systemic issue, promoting a vicious circle of stress. The more suppressed the metabolism becomes, the more the effects of exercise are able to lead to further suppression.

“This study indicates that the pronounced initial systemic inflammatory response induced by an Ironman triathlon declines rapidly. However, a low-grade systemic inflammation persisted until at least 5 days post-race, possibly reflecting incomplete muscle recovery.”

“Marathon runners developed AKI [acute kidney injury] and urine sediment diagnostic of tubular injury. An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon.”

The direct relationship between digestive distress and the promotion of aging and degenerative disease, is not commonly talked about, and many don’t realize they’re functioning in a gradually increasing – metabolism suppressing – state of stress, or that there is a direct relationship between a lot of their symptoms.

“There was a high incidence (93% of all participants) of GI symptoms; 45% reported severe complaints and 7% of the participants abandoned the race because of severe GI distress…LPS [endotoxin] does enter the circulation after ultra-endurance exercise and may, together with muscle damage, be responsible for the increased cytokine response and hence GI complaints in these athletes.”

It’s Good, Bad And Ugly

There are many positives which come from exercise (including circumstances arising alongside its performance), and the body’s response to stress can – at least for a while – make a person feel good (or better than before exercise), even when there is damage being done, leading to confusion.

Exposure to daylight as well as new and interesting environments; enjoyable social interactions; having something to be passionate and excited about; a sense of purpose: these and many other things that aren’t a direct physical effect of exercise, can improve metabolism and health.

Movement of varying kinds is important for proper metabolic function, and some stress – supported by sufficient energy – can lead to adaptive changes. The ‘right’ approach to exercise can powerfully promote improvement. Just raising your body temperature can be beneficial.

It’s all very context dependent, and how much is too much changes from one individual to the next. A one size fits all ‘exercise is good for you’ methodology can be dangerous, especially as a person gets older and is using exercise for healing, weight loss or illness prevention.

“…our results suggest that there is a similar risk of sudden cardiac death, due to increased whole blood viscosity, after short-term heavy or light exercise.”

“Endurance training may be associated with arrhythmogenic cardiac remodelling of the right ventricle (RV)…Although short-term recovery appears complete, chronic structural changes and reduced RV function are evident in some of the most practiced athletes…”

Chronic dieting and exercise gets more stressful and dangerous the more metabolically sensitive a person becomes. Because this kind of approach can be difficult to sustain, and can have a suppressive impact on thyroid function, it often fails to achieve long term results. What looks like ‘fitness’ – or improved endurance – can be a sign of hypo-metabolism.

“…we showed that a drop in resting metabolism during active weight loss…probably cannot be avoided by the addition of an exercise program…which may predispose to weight regain unless the participants maintain high levels of physical activity or significant caloric restriction.”

“Findings of our study demonstrate that exhaustion exercise led to a significant inhibition of both thyroid hormones and testosterone concentrations…”

Stress and metabolic suppression can interfere with biological processes, and sometimes shows up as a disturbance in the menstrual cycle, or as a reduction in sexual function.

“Subtle menstrual disturbances that affect the largest proportion of physically active women and athletes…are associated with a metabolic hormone profile indicative of a hypometabolic state…”

“Exposure to higher levels of chronic intense and greater durations of endurance training on a regular basis are significantly associated with a decreased libido scores in men.”

Although there is often great benefit from weight bearing or resistance exercise – if done excessively or inappropriately – this too can compound inflammatory issues, rather than lead to improvement or healing.

“…weightlifting resulted in profound increases in the liver function parameters…this effect was prolonged…in line with a recent study…in which all markers of muscle damage were significantly increased for up to 10 days after exercise.”

Metabolism Matters

Metabolic deterioration from continuous or excessive stress – including the stress of exercise without proper nutritional support – can take time to become noticeable. The effects of stress are often cumulative, and some people – like the young and healthy with strong and resilient metabolic function – can be (or look like they are) in great shape, in spite of the fact that their training regime might be causing harm in the long run.

Studying the effects of exercise on the young, and using the findings to make recommendations for the aging or unwell, is especially risky because of certain misleading ideas which have gained a stronghold in the medical and ‘scientific’ arenas.

The impact of sugar restriction on stress regulation – in relation to cortisol, serotonin, estrogen and the polyunsaturated free fatty acids – can have far more immediate consequences for an older or sicker population.

“…this study demonstrates that brain glucose can act on serotonergic metabolism and thus can prevent exercise-induced increase of 5-HT levels.”

“Chronic exercise seems to increase the proportion of polyunsaturated fatty acids and omega6 fatty acids…in animal and human adipose tissue.”

You Can’t Run From Depression

Incorrect physiological principles can lead to confusion regarding some of the possible effects of exercise on health and disease. It’s true that exercise of different kinds (and some of the things that go along with it) can help with depression. Chronic stress however – including anything that causes hyperventilation, inflammation, digestive distress and a rise in the thyroid suppressing substances (like serotonin, estrogen, cortisol and endotoxin) – can be a driving force behind many psychological disorders, including anxiety and depression.

Symptoms of depression can creep up over time, and the causes are often attributed to anything but exercise, especially as people tend to feel good after doing it. Other problems which arise along the way – like sleep or stomach issues, skin disorders, infections, chronic fatigue – are usually treated as though they are not related to each other or to excessive training.

For those who are already at higher risk, the dangers can be far greater and the symptom progression is often significantly less subtle. There is plenty of great new and old science available – as well as some highly skilled trainers and other practitioners – but separating fact from fiction can be very time consuming.

So by all means go for a walk, lift some weights, do some stretching, ride a bike, do whatever it is that you like to do. If you want to go for a run, maybe first run to the kitchen and grab a coke. But beware, more exercise is not necessarily better, some things that feel good now can be more harmful than realized, and popular dietary advice is often counterproductive.

I’m not a doctor or an exercise physiologist, but I believe the idea that exercise (no matter who you are, which kind and how much you do, and how you fuel it) is necessarily beneficial, might turn out to be one of the most damaging myths around. It certainly has created some pretty big industries and some huge profits.

See More Here

The Impact of a 24-h Ultra-Marathon on Circulatory Endotoxin and Cytokine Profile.

The effects of four weeks aerobic training on saliva cortisol and testosterone in young healthy persons

Effect of exhaustive exercise on membrane estradiol concentration, intracellular calcium, and oxidative damage in mouse thymic lymphocytes.

Changes in blood viscosity with heavy and light exercise.

Recovery after an Ironman triathlon: sustained inflammatory responses and muscular stress.

Muscular exercise can cause highly pathological liver function tests in healthy men.

High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation.

Endurance Exercise Training and Male Sexual Libido.

Changes in renal markers and acute kidney injury after marathon running.

Kidney Injury and Repair Biomarkers in Marathon Runners

Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes.

Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity.

The acute phase response and exercise: the ultramarathon as prototype exercise.

Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention.

Abdominal symptoms during physical exercise and the role of gastrointestinal ischaemia: a study in 12 symptomatic athletes.

Upper gastrointestinal issues in athletes.

Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men.

Metabolic slowing with massive weight loss despite preservation of fat-free mass.

The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc.

Menstrual disturbances in athletes: a focus on luteal phase defects.

Caffeine inhibits exercise-induced increase in tryptophan hydroxylase expression in dorsal and median raphe of Sprague-Dawley rats.

Prevalence and characteristics of asthma in the aquatic disciplines

Serotonin and central nervous system fatigue: nutritional considerations.

Evidence that brain glucose availability influences exercise-enhanced extracellular 5-HT level in hippocampus: a microdialysis study in exercising rats.

Effects of graded carbohydrate supplementation on the immune response in cycling.

Influence of acute vitamin C and/or carbohydrate ingestion on hormonal, cytokine, and immune responses to prolonged exercise.

Beneficial effect of aspirin against interferon-α-2b-induced depressive behavior in Sprague Dawley rats.

Acute stress persistently enhances estrogen levels in the female rat.

Effects of exercise on the fatty-acid composition of blood and tissue lipids.



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