The belief that physical and psychological symptoms should be treated separately may be profitable for some, but it’s rarely the best way to support lasting metabolic health and true well-being.

Look deeper and you’ll see mood and anxiety disorders (chronic depression, generalized anxiety, even bipolar and schizophrenia) almost always come with physical or metabolic problems. This isn’t just chance.

‘Findings suggest that mental disorders are antecedent risk factors of certain physical diseases in early life, but also vice versa.’ (Tegethoff M, et al., 2016)

‘The most substantial associations included those between affective disorders and diseases of the digestive system…anxiety disorders and arthritis…anxiety disorders and heart diseases…mental disorders and physical diseases often co-occur in childhood.’ (Tegethoff M, et.al., 2015)

‘In…adults with MDD (major depressive disorder), we found that a single session of WBH [whole-body hyperthermia] was significantly associated with a reduction in depressive symptoms when measured 5 days after treatment.’ (Janssen CW, et al., 2016)

Despite all this, metabolic problems are still mostly treated like minor side issues instead of being recognized as deeply connected to mood disorders. This includes digestive troubles, chronic low-level inflammation, oxidative stress, blood sugar imbalances, and hypothyroidism.

The bigger problem is, we’re often taught not to think about how mental and physical symptoms connect. So most people don’t notice or understand what’s really going on.

But in reality, psychological instability is closely tied to metabolic function—and with good science, you can easily see the connection goes both ways.

I’m not saying emotions or spiritual things aren’t important—they are. But when metabolism falters, the mind feels it. And when your mental state shifts, your body shows it. Knowing this could open up new ways to treat illness.

‘Chronically high anxious arousal and inflammation increase one’s risk of developing type 2 diabetes…’ (Murdock KW, et al., 2016)

‘…increased incidence of depression in patients with diabetes can be a consequence of central insulin resistance.’ (Kleinridders A, et al., 2015)

‘…5HT [serotonin] release after stress showed a significant increase with helpless behavior…’ (Petty F, et al., 1994)

‘…significant proportion of patients with depression exhibit increased inflammation, as measured by…inflammatory cytokines and acute-phase reactants, such as C-reactive protein…’ (Felger, J., et al., 2016)

‘…we expect the exogenous administration of a single dose of 400 mg pregnenolone to reduce [and normalize] the amplitude response of the amygdala that is known to be increased in lonely individuals.’ (Cacioppo S, Cacioppo JT. 2015)

The trouble is, “official” approaches to mind and body issues often contradict themselves, fueled by entrenched beliefs that make it hard to see the straightforwardness of healthy metabolic function. These old habits and ways of thinking get in the way of simple, logical solutions that could actually make a difference.

There’s really little reason to think that treating physical symptoms should make psychological symptoms worse—or the other way around. In fact, the idea that better outcomes come from treating both together is much more reasonable, and well-supported by real-world results

‘Examination of metabolic disorders in treatment-refractory depression identified an unexpectedly large proportion of patients with potentially treatable abnormalities.’ (Pan LA, et. al., 2017)

‘When patients with depression were compared with healthy controls, depression was associated with higher oxidative stress MDA [breakdown product of PUFA] levels…’ (Jiménez-Fernández S, et. al., 2015)

Much of what’s now considered “established” science about nutrition and treatment has been shaped by decades of industry-driven and politically influenced propaganda, with plenty of biased, poorly designed studies (and even outright manipulation and fraud) along the way.

Faulty core ideas about health and disease can be so deeply embedded that they become almost invisible. But seen or not, they still shape the decisions made and the results that follow. Sadly, unless these false assumptions are exposed, people rarely realize how much they’ve influenced things.

‘Increased caloric intake since 1970…not due to added sugars (including HFCS)…rather…due to increased consumption of all caloric nutrients,especially fats and flour and cereals…’ (White JS., 2013)

‘One of the most nutritionally important features of plant lectins is their ability to survive digestion by the gastrointestinal tract of consumers…they can disrupt lipid, carbohydrate and protein metabolism, promote enlargement and/or atrophy of key internal organs and tissues and alter the hormonal and immunological status…’ (Vasconcelos IM, Oliveira JT., 2004)

‘…a number of fermentable fiber supplements including pectin, corn bran, oat bran, undegraded carageenan, agar, psyllium, guar gum, and alfalfa have been shown to enhance tumor development.’ (Jacobs LR., 1986)

Common sayings like “all things in moderation,” “eat your vegetables,” or “follow a clean eating plan” sound helpful but often mislead. They usually offer little real guidance and are based on flawed or misunderstood nutrition science.

The so-called moderation rule often leads people toward calorie restriction and under-eating, while what they really need is higher-quality fuel—and more of it.

‘…dieting is ineffective because it is a stressor…Chronic stress, in addition to promoting weight gain, has been linked with a host of negative health outcomes such as atherosclerosis, coronary heart disease, hypertension, diabetes, cancer, and impaired immune functioning…’ (Tomiyama AJ, et al., 2010)

‘…lowering levels of…serotonin…reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure.’ (Carey AL, Kingwell BA., 2015)

The notion of just eating a balanced diet to improve health loses its impact once you look closely at the shaky scientific reasoning behind what’s considered the “right” balance of foods and portions.

‘HFCS has the same sugars composition as other “benign” fructose-glucose sweeteners such as sucrose, honey, and fruit juice concentrates and dietary sources such as fruits and juices…’ (White JS., 2008)

‘…presence of…anti-nutritional and toxic factors in food legumes…substances include proteolytic inhibitors, phytohemagglutinins, lathyrogens, cyanogenetic compounds, compounds causing favism, factors affecting digestibility and saponins…’ (Gupta YP., 1987)

‘…significant change in the Western diet, concurrent with the obesity epidemic, was a substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA)…The diet with 22.5% LA caused greater bodyweight gain, decreased activity, and insulin resistance compared to control and 1% LA…’ (Mamounis KJ,, 2017)

‘…sugar may provide the fuel needed to meet the energetic demands of stress, which may reduce the need for glucocorticoid-driven energy catabolism and mobilization of the body’s energy stores…’ (Tryon MS,, et. al., 2015)

High-fiber, vegetable-heavy “clean eating” isn’t really clean. It’s based on flawed science that overlooks how many raw vegetables contain anti-metabolic substances that disrupt digestion, promote stress, feed harmful bacteria, and trigger inflammation when consumed in excess.

It’s even harder to see the real damage these ideas cause because of the flood of low-quality studies that wrongly claim many stress-related biochemical substances actually improve metabolic health.

Serotonin is a perfect example. It’s often wrongly called the “happiness hormone,” suggesting that psychological problems come from having too little of it, which oversimplifies the reality.

Increasingly, research confirms what multiple studies over the years have shown: serotonin can actually promote symptoms of depression, anxiety, and mood instability.

‘…these data reveal a discrete 5-HT responsive circuit…that underlies pathological anxiety and fear associated with a hyperserotonergic state…SSRIs are currently a first-line treatment for anxiety and panic disorders but can acutely exacerbate symptoms, resulting in poor therapeutic compliance.’ (Marcinkiewcz CA,, 2016)

The idea that higher serotonin levels improve mental state makes little sense when you consider how elevated serotonin is linked to metabolic problems like digestive distress, chronic inflammation, degenerative diseases, obesity, and cancer.

Add to that the link between increased bacterial endotoxin and rising serotonin (along with other stress chemicals like nitric oxide and estrogen) in relation to digestion and mental state, and the notion that depression or anxiety is simply a low-serotonin condition doesn’t hold up.

‘More than 90% of the body’s 5-HT (serotonin) is synthesized in the gut…the microbiota promotes 5-HT biosynthesis…targeting the microbiota can serve as a tractable approach for…treating 5-HT-related disease symptoms.’ (Yano JM, et al., 2015)

‘…96 patients undergoing liver resection for malignant liver tumors…Patients with high IP5-HT [intra-platelet serotonin] levels…exhibited a reduction in morbidity, severe morbidity and LD [liver dysfunction]…patients receiving selective serotonin reuptake inhibitor treatment…displayed…an increase in postoperative morbidity…’ (Padickakudy R, et al., 2017)

‘…results suggest that endogenously released 5-HT [serotonin] activates 5-HT2A receptors to aggravate cerulein-induced pancreatitis. We propose that selective 5-HT2A antagonists may provide a new therapy for acute pancreatitis.’ (Hamada K, et al., 2007)

‘…serotonin has more recently emerged as a growth factor for human tumor cells of different origins (carcinomas, glioma and carcinoids). Several data are also available on serotonin involvement in cancer cell migration, metastatic dissemination and tumor angiogenesis…The results of several studies showed that serotonin levels in the tumor played a crucial role in cancer progression.’ (Sarrouilhe D, Mesnil M., 2019)

Though the idea that rising serotonin causes learned helplessness and mood disorders isn’t new, it hasn’t stopped the ongoing promotion and sale of profitable drugs designed to boost 5-HT levels.

There’s no solid reason to think increasing a substance that directly slows metabolism (including brain metabolism) would help psychological problems, unless you believe a “deficiency” in that substance is somehow worse. If so, you’d have to accept that suppressing metabolism is the solution, and while some argue this, I’ve never heard a convincing, logical case. Serotonin’s link to promoting brain tumors should be a clear warning by itself.

‘…increasing extracellular serotonin, SSRIs disrupt energy homeostasis and often worsen symptoms during acute treatment…symptom reduction is not achieved by the direct pharmacological properties of SSRIs, but by the brain’s compensatory responses that attempt to restore energy homeostasis. These responses take several weeks to develop, which explains why SSRIs have a therapeutic delay.’ (Andrews PW, et. al., 2015)

When drugs fail or even make symptoms tied to chronic stress and serotonin worse, those results are often ignored or dismissed as unrelated “side effects.”

‘…adverse effects studied were reported by over half the participants; most frequently Sexual Difficulties (62%) and Feeling Emotionally Numb (60%). Percentages for other effects included: Feeling Not Like Myself – 52%, Reduction In Positive Feelings – 42%, Caring Less About Others – 39%, Suicidality – 39% and Withdrawal Effects – 55%.’ (Read J, et al., 2014)

‘…use of SSRIs and more generally of antidepressants with strong inhibition of serotonin reuptake are associated with an increased risk for ICH [intracranial hemorrhage], particularly in the first 30 days of use…’ (Renoux C, et al., 2017)

‘In patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.’ (Würtz M, et al., 2016)

Biased and inaccurate reporting of treatment results clouds the true connections between related problems. This makes it really hard to apply clear thinking and a holistic approach to tackle multiple issues at once.

‘Pregnenolone (PREG) and L-Theanine (LT) have shown ameliorative effects on various schizophrenia symptoms…blunted affect, alogia, and anhedonia…were found to be significantly improved…PREG-LT also significantly associated with a reduction of anxiety scores such as anxious mood, tension, and cardiovascular symptoms…and elevation of general functioning…’ (Kardashev A,, et al, 2018)

‘…our findings show that prostaglandin-mediated modulation of serotonergic transmission controls the affective component of inflammatory pain.’ (Singh AK, et al., 2017)

‘…rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium…with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited.’ (Eby GA, Eby KL., 2006)

It’s no surprise people get confused when so-called “health foods” that boost serotonin and nitric oxide (or are packed with harmful polyunsaturated fats) end up causing digestive issues and making anxiety and depression worse.

You’re more likely to believe something is helping you, even if it makes you feel sick, when there’s a big gap between how your body actually works and the popular advice about health and wellness.

Taking a broader look at the history of physiology helps reveal how symptoms are connected—something too often overlooked today when conditions get treated as if they have nothing to do with each other.

‘Cyproheptadine was effective in improving symptoms of functional abdominal pain, functional dyspepsia, in a relatively larger number of patients. Patients in smaller numbers had significant improvement 13/18 (72%) abdominal migraine, 10/10 (100%) IBS, and 6/8 (75%) cyclic vomiting syndrome. This is the first time report of improvement in IBS.’ (Madani S, et al., 2016)

‘There was a significantly stronger expression of serotonin in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in patients with chronic eczema. There was no positive expression of serotonin in normal skin.’ (Huang J, et al., 2004)

‘Stress and stress-induced anxiety play a major role in functional intestinal disorders…our data propose a therapeutic use of Lys [l-lysine] in the treatment of stress-related intestinal disorders, in which 5-HT sensitization and concurrent anxiety disorder are diagnosed.’ (Smriga M, Torii K., 2003)

‘…data support the hypothesis that 5-HT2B [serotonin] receptors located on endothelial cells of meningeal blood vessels trigger migraine headache through the formation of nitric oxide.’ (Schmuck K, et al., 1996)

When we talk about the biochemistry of stress honestly and with a clear, big-picture view, many overlooked or misunderstood interactions start to appear as important clues for improving metabolism. This includes how excess estrogen or serotonin relates to stress and disease, how sugar and salt intake affect mood, and the role of inflammation caused by PUFA breakdown in metabolic disorders.

‘Women are twice as likely to suffer from depression as men…instances of depression in females are associated with levels of reproductive hormones and their fluctuations across time…the change in level of estrogen is critical…exposure to the stressor…increases estrogen…evidence that a disruption in the HPA activity is associated with depression, at least in males…’ (Shors TJ, Leuner B., 2003)

‘…evidence that consumption of beverages sweetened with sugar, but not the artificial sweetener aspartame, inhibits stress-induced cortisol secretion in humans….sugar consumption…associated with greater activation of the hippocampus, which is typically inhibited during acute stress…’ (Tryon MS, et al., 2015)

‘…evidence for direct estrogenic regulation of CRF gene expression provides a compelling mechanism for sexual dimorphism of stress reactivity and prevalence of stress-related psychopathology in women…’ (Bangasser, et al., 2010)

‘Several studies have shown a positive association between depression and obesity…Selected sex hormone parameters were significantly different in overweight and obese compared to normal weight males…Depressive symptomatology was associated with increased estradiol levels in younger men, regardless of BMI.’ (Stanikova D, et al., 2018)

A clearer understanding of metabolism would naturally reveal how different factors work together, not separately.

‘…progesterone treatment decreased serum corticosterone compared to the controls and sham….results indicate that single dose progesterone may be effective for treating anxiety caused by TBI (traumatic brain injury).’ (Baykara B, et al., 2013)

Sadly, as long as industry and government are the driving forces behind what gets produced and promoted, biological principles related to nutrition and disease, showing ways to effectively approach a wide range of health problems, are unlikely to play a major role.

I’m not a doctor or scientist, and none of this is medical advice. But as long as misinformation and confusion shape what’s seen as safe or helpful, official treatments and disease prevention (whether physical or mental) are unlikely to offer solid guidance for truly improving metabolism.

‘…results strongly implicate 5-HT engagement…in acute SSRI induced aversive behaviours…and could potentially be involved in the early adverse events seen in clinical populations…’ (Marcinkiewcz CA, et al., 2016)

‘The time differential between the onset of 5HT reuptake inhibition by SSRIs (minutes) and onset of their antidepressant efficacy (weeks to months), when considered with their overall poor therapeutic effectiveness, has cast some doubt on the role of 5HT in depression…’ (Angoa-Pérez M, et al., 2014)

Many still believe that “they’re searching for a cure” and “have our best interests at heart”, but what if that’s just another product of conditioned, unexamined thought bubbles?

See more here

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#serotoninsorrow
#estrogeneration
#sugarsaves
#raypeat

Image: yogajournal.ru/body/practice/home-practice/ya-plakal-top-10-samykh-smeshnykh-yoga-kartinok/Jun

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