5HTrouble Serotonin (5-HT), although popularly referred to as the ‘happiness hormone’, is a biogenic amine produced mainly in the intestines in response to stress and irritation. The association between digestive distress and mood fluctuations is well known.

Increased serotonin levels have been linked to the onset and development of many diseases from MS, Alzheimer’s, and Parkinson’s, to Autism, Irritable Bowel Syndrome, Crohn’s disease, cancer, and more.

Contrary to popular belief, much research has shown serotonin to be part of an inhibitory system of harm avoidance. The relationship between increased serotonin and depression has been compared to biological role of serotonin in hibernation.

Although humans technically don’t hibernate, serotonin suppresses metabolism thereby interfering with glucose utilization – reducing brain function and promoting the oxidation of fat for fuel – mimicking many aspects of torpor.

Serotonin production is promoted by the polyunsaturated fats (PUFAs) as well as by foods or substances that irritate or interfere with digestion, encouraging bacterial growth. Bacterial toxins are known promoters of anxiety and aggressive behavior.

Intestinal serotonin secretion increases in direct response to rising levels of bacterial endotoxin release, and many studies have confirmed the inflammation and disease promoting effects of rising levels of endotoxin passing into the blood stream.

The more serotonin interferes with metabolism – slowing digestion and intestinal barrier function – the harder it is for the liver to carry out its detoxification functions, allowing increasing levels of the stress substances (including estrogen, serotonin, endotoxin, and the polyunsaturated free fatty acids) to interact with each other throughout the main system leading to what can become a vicious circle of degeneration.

Apart from the seed and fish oil PUFAs, other foods like too many fibrous under cooked vegetables, grains, beans, nuts, seeds, and legumes, and various starches, can also promote serotonin secretion.

Foods that have been shown to be able to improve metabolism and reduce serotonin, include dairy products, sweet ripe fruits, and simple sugars like honey or sucrose.

A variety of anti-serotonergic drugs have also been used to successfully treat depression and numerous related diseases of inflammation and high serotonin.

Copyright 2021, by Dan M @ CowsEatGrass. All rights reserved (except for quotations and images having their own protected copyrights). This copyright protects author-publisher Dan M’s right to future publication of his work in any manner, in any and all media — utilizing technology now known or hereafter devised — throughout the world in perpetuity. Everything described in this publication is for information purposes only. The author-publisher, Dan M, is not directly or indirectly presenting or recommending any part of this publication’s data as a diagnosis or prescription for any ailment of any reader. If anyone uses this information without the advice of their professional health adviser, they are prescribing for themselves, and the author- publisher assumes no responsibility or liability. Persons using any of this data do so at their own risk and must take personal responsibility for what they don’t know as well as for what they do know.

See more here.

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation

Mast Cells Play a Crucial Role in Staphylococcus aureus Peptidoglycan-Induced Diarrhea

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

Brain serotonin metabolism in hibernation

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function.


You may also like...

Leave a Reply

Your email address will not be published. Required fields are marked *