Out Beyond Ideas…There Is A Tissue Organization Field

‘The somatic mutation theory (SMT) of carcinogenesis has been the dominant force driving cancer research during the 20th century. In brief, it proposes that successive DNA mutations in a single cell cause cancer…We propose the adoption of an alternative theory, the tissue organization field theory (TOFT) of carcinogenesis…We argue that it is necessary to abandon the somatic mutation theory.’ (C Sonnenschein, A M Soto, 2000)

Many physiological and environmental factors, including hormonal responses to radiation exposure, and toxic chemicals in food and water, have been demonstrated to interfere with proper cellular function.

‘We challenge the notion that cancer is a cellular problem caused by mutated genes….an alternative view….tissue organization field theory (TOFT), is based on premises that…carcinogenesis represents a problem of tissue organization…’ (Ana M Soto, Carlos Sonnenschein, 2005)

‘The regulatory power of a mass of….normal cells is expressed in its capacity to normalize the appearance and growth behavior of solitary…neoplastic cells’ (Harry Rubin, 2006)

An underactive thyroid metabolism causes the release of polyunsaturated fats (PUFAs) out of storage. As a result, it interferes with digestion and liver function. And it promotes serotonin, estrogen, and many other inflammatory stress substances, which can all help to drive and sustain field disorganization, promoting cancer.

‘…the differences between normal and cancerous states are instead identifiable at the tissue level of biological organization, and therefore, the search for identification of a cancer cell should be abandoned.’ (Carlos Sonnenschein, Ana M Soto, 2011)

‘Normal growth behavior is reintroduced in solitary, carcinogen-initiated…cells by contact with an excess of normal…cells’ (Harry Rubin, 2007)

A diet that avoids PUFAs with sufficient protein, vitamins and minerals, and simple sugars from milk, cheese, gelatin, sweet ripe, juicy fruits and juices, sugar and honey is a helpful way to prevent excess inflammation and cancer development.

‘Metastases are tumors that develop at a distance from their primary origin and are responsible for the death of 90% of cancer patients…Based on the…shortcomings of the SMT and the acknowledged failure of therapeutic approaches based on this theory, we conclude that TOFT explains comprehensibly carcinogenesis and the appearance of metastases.’ (Carlos Sonnenschein, Ana M Soto, 2015)

I’m not a doctor or health practitioner; this is not medical or health advice. Still, if you want to know more about cancer as a metabolic stress disease, check out my books Everything Estrogen Made Easy and Please Don’t Fix My Cholesterol: Cancer Protection & A Happy Heart.

See more here.

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Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease. Oncotarget. 2015 Mar 10;6(7):4569-84.

Rubin H. Ordered heterogeneity and its decline in cancer and aging. Adv Cancer Res. 2007;98:117-47.

Rubin H. What keeps cells in tissues behaving normally in the face of myriad mutations? Bioessays. 2006 May;28(5):515-24.

Sonnenschein C, Soto AM. Cancer Metastases: So Close and So Far. J Natl Cancer Inst. 2015 Aug 17;107(11):djv236.

Sonnenschein C, Soto AM. Le cancer et ses gènes insaisissables [Cancer and the elusive cancer genes]. Med Sci (Paris). 2014 Jun-Jul;30(6-7):688-92. French.

Sonnenschein C, Soto AM. Somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol Carcinog. 2000 Dec;29(4):205-11. 

Sonnenschein C, Soto AM. The death of the cancer cell. Cancer Res. 2011 Jul 1;71(13):4334-7.

Soto AM, Sonnenschein C. Emergentism as a default: cancer as a problem of tissue organization. J Biosci. 2005 Feb;30(1):103-18. 

Soto AM, Sonnenschein C. The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory. Bioessays. 2011 May;33(5):332-40.

#pufaispoison
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Image: “Killing Cancer Cells”
Artist: JerryKongArt

Copyright 2021, by Dan M @ CowsEatGrass. All rights reserved (except for quotations and images having their own protected copyrights). This copyright protects author-publisher Dan M’s right to future publication of his work in any manner, in any and all media — utilizing technology now known or hereafter devised — throughout the world in perpetuity. Everything described in this publication is for information purposes only. The author-publisher, Dan M, is not directly or indirectly presenting or recommending any part of this publication’s data as a diagnosis or prescription for any ailment of any reader. If anyone uses this information without the advice of their professional health adviser, they are prescribing for themselves, and the author- publisher assumes no responsibility or liability. Persons using any of this data do so at their own risk and must take personal responsibility for what they don’t know as well as for what they do know.