Big Aspirin.

BigAspirin “Inflammation, interfering with cellular energy production, is probably the essential feature of the things called diabetes.”
Ray Peat Phd

Despite the fact that sugar is still popularly believed to be responsible for the onset of type 2 diabetes and other related illnesses, experiments suggest otherwise, pointing to inflammation and associated factors, including insulin resistance, hyperglycaemia, and high levels of fat in the blood, particularly the polyunsaturated fats.

Although dietary measures – including limiting fat intake and increasing consumption of easy to digest protein and sugars – directly help to suppress cortisol (as well as other inflammatory stress hormones) and the release of the polyunsaturated fats from storage – both significant promoters of the above mentioned factors involved in the development of type 2 diabetes – high dose aspirin has been shown to be a highly effective and safe therapeutic approach.

“We found that a 2-week trial of high-dose aspirin treatment (∼7 g/d) was accompanied
by significant decreases in hepatic glucose production (22%), fasting plasma glucose…about 40 mg/d…(24%), fatty acids (50%)…and a 19% increase in peripheral glucose disposal.”

“…despite similar plasma insulin concentrations, aspirin treatment still resulted in a higher…rate of insulin-stimulated glucose disposal…, reflecting increased…insulin responsiveness.”

“Aspirin therapy also resulted in significant reductions in…plasma fatty acid concentration, and such reductions can also contribute to enhanced insulin action…”

“There was no significant change in body weight….All the patients completed the study with no major side effects….”

“There were also significant decreases in concentrations of…C-reactive protein (17%)” reflecting a reduction in inflammation.

In summary – through mechanisms which promote a significant decrease in inflammation as well as free fatty acids – high dose aspirin treatment improved all measures of hyperglycaemia, caused an appreciable increase in insulin sensitivity and glucose oxidation, vastly improving symptoms of patients with type 2 diabetes without any noticeable serious or long term side effects.

In a similar fashion, sufficient consumption of sugar – in the form of sweet ripe juicy fruits and fruit juices as well as honey and white sugar – promotes improvements in thyroid function, limiting the release of the polyunsaturated fats from storage, reducing the secretion of inflammatory stress substances including cortisol, ameliorating insulin resistance, protecting against hyperglycaemia, increasing cellular energy production, and preventing, as well as improving the symptoms of type 2 diabetes and other related conditions including obesity, cardiovascular disease and cancer.

For a closer look, have a read through this and some other related studies attached below.

See more here

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.

Prevention of fat-induced insulin resistance by salicylate

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.

Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.

Mechanism of free fatty acid-induced insulin resistance in humans.

Mechanisms of Fatty Acid-Induced Insulin Resistance in Muscle and Liver

Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 diabetes: a randomized clinical trial.

#aspirintherapy
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Image: ACP InternistWeekly: Artist Unknown
“We find that compliance improves when you only have to take one pill a day.”

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