Big Aspirin.

BigAspirin “Inflammation, interfering with cellular energy production, is probably the essential feature of the things called diabetes.”
Ray Peat Phd

Despite the fact that sugar consumption is popularly believed to be responsible for the onset of type 2 diabetes and related illnesses, experiments suggest otherwise, pointing to inflammation and associated factors including insulin resistance, blood sugar dysregulation, and high levels of fat in the blood, particularly polyunsaturated fats.

Dietary measures, including limiting fat intake and increasing consumption of easy to digest sugars have been shown to be able to help lower cortisol and the release of the polyunsaturated fats (PUFAs) out of storage.

Both of these stress metabolism signs (rising cortisol and exposure to PUFAs) are known to be involved in promoting the symptoms of diabetes, and there is science showing that aspirin can be an effective and safe therapy.

“We found that a 2-week trial of high-dose aspirin treatment (∼7 g/d) was accompanied
by significant decreases in hepatic glucose production (22%), fasting plasma glucose…about 40 mg/d…(24%), fatty acids (50%)…and a 19% increase in peripheral glucose disposal…

…despite similar plasma insulin concentrations, aspirin treatment still resulted in a higher…rate of insulin-stimulated glucose disposal…reflecting increased…insulin responsiveness…

…Aspirin therapy also resulted in significant reductions in…plasma fatty acid concentration, and such reductions can also contribute to enhanced insulin action…

…There was no significant change in body weight…All the patients completed the study with no major side effects…

…There were also significant decreases in concentrations of…C-reactive protein (17%)” (Ripudaman S. Hundal, et al., 2002)

The above quotations taken from one study, showed that via mechanisms which decreased inflammation and free fatty acid release, aspirin treatment improved all measures of hyperglycemia, caused an appreciable increase in insulin sensitivity and glucose oxidation, and vastly improved symptoms of patients with type 2 diabetes without any noticeable serious or long term side effects.

Similarly, sufficient consumption of sugar from sweet ripe juicy fruits, fruit juices, honey and white sugar, is thought by some to be able to promote improvements in thyroid function, limiting stress and the release of PUFAs out of storage.

It makes sense from a biological perspective, that this might then be able to help reduce exposure to the inflammatory stress substances including cortisol, thereby ameliorating insulin resistance, protecting against hyperglycemia, increasing cellular energy production, and protecting against the development or worsening of type 2 diabetes symptoms and related conditions including obesity, cardiovascular disease, and cancer.

Have a read through the study mentioned and the rest of the studies attached below and make up your own mind.

I’m not a doctor and this is not intended as a prescription or as any kind of health advice, but information like this is available for all to go through, and I think it’s a good idea to at least have a look.

Copyright 2021, by Dan M @ CowsEatGrass. All rights reserved (except for quotations and images having their own protected copyrights). This copyright protects author-publisher Dan M’s right to future publication of his work in any manner, in any and all media — utilizing technology now known or hereafter devised — throughout the world in perpetuity. Everything described in this publication is for information purposes only. The author-publisher, Dan M, is not directly or indirectly presenting or recommending any part of this publication’s data as a diagnosis or prescription for any ailment of any reader. If anyone uses this information without the advice of their professional health adviser, they are prescribing for themselves, and the author- publisher assumes no responsibility or liability. Persons using any of this data do so at their own risk and must take personal responsibility for what they don’t know as well as for what they do know.

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J Clin Invest. 2002 May 15; 109(10): 1321–1326. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. Ripudaman S Hundal, Kitt F Petersen, Adam B Mayerson, Pritpal S Randhawa, Silvio Inzucchi, Steven E Shoelson, Gerald I Shulman 

J Clin Invest. 2001 Aug 1; 108(3): 437–446. Prevention of fat-induced insulin resistance by salicylate. J K Kim, Y J Kim, J J Fillmore, Y Chen, I Moore, J Lee, M Yuan, Z W Li, M Karin, P Perret, S E Shoelson, G I Shulman

Science. 2001 Aug 31;293(5535):1673-7. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. M Yuan, N Konstantopoulos, J Lee, L Hansen, Z W Li, M Karin, S E Shoelson

Diabetes. 2012 Apr; 61(4): 790–796. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Mark Nixon, Deborah J. Wake, Dawn E. Livingstone, Roland H. Stimson, Cristina L. Esteves, Jonathan R. Seckl, Karen E. Chapman, Ruth Andrew, and Brian R. Walker

J Clin Invest. 1996 Jun 15; 97(12): 2859–2865. Mechanism of free fatty acid-induced insulin resistance in humans. M Roden, T B Price, G Perseghin, K F Petersen, D L Rothman, G W Cline, and G I Shulman

Journal of Diabetes & Metabolism 02(04) January 2011 Mechanisms of Fatty Acid-Induced Insulin Resistance in Muscle and Liver. Rafik Ragheb, Amina Medhat

Diabetes Care. 2015 Oct;38(10):1820-6. Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 diabetes: a randomized clinical trial. Jakubowicz D, Wainstein J, Ahren B, Landau Z, Bar-Dayan Y, Froy O.


Image: ACP InternistWeekly: Artist Unknown
“We find that compliance improves when you only have to take one pill a day.”

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