Joyous Jelly Jammin

HappyGel Many popular ideas in relation to amino acid requirements have been influenced by evidence regarding their impact upon growth rather than health and longevity.

Cancer can be seen as a disease of excessive growth, and requirements for the ‘essential’ amino acids tryptophan and cysteine decrease as we reach adulthood.

Gelatin is free of tryptophan, has only small amounts of other inflammatory amino acids, and is a great source of the protective amino acids, in particular glycine.

Excess tryptophan and cysteine inhibit thyroid function and metabolism – promoting inflammation and the release of polyunsaturated fats from storage – whereas glycine is generally pro-metabolic.

“Only glycine…inhibited the TRH-stimulated TSH secretion…”

Polyunsaturated fats cause further inflammation, increasing levels of the cytokines, including tumor necrosis factor (TNF), nitric oxide (NO) and the prostaglandins, promoting growth hormone and tumor development.

“Corn oil increased cell proliferation ~3.5-fold in hepatocytes…However, olive oil and MCT had no significant effect on hepatocyte proliferation.”

Glycine, proline and alanine – all found in large amounts in gelatin – are cytoprotective, anti-inflammatory and inhibit growth hormone release.

Glycine promotes healing and inhibits the growth of tumors, and the excessive formation of blood vessels common in cancer.

“In vivo treatment with glycine blocks tumor growth and artery formation in tumors…Therefore, glycine can be used not only for treatment of inflammation, but also for chemoprevention and treatment of carcinoma.”

Balancing amino acids with glycine or gelatin generally protects against stress, fibrosis, free radical damage, inflammation and disease.

Glycine inhibits the release of the polyunsaturated fats and cortisol – and protects against the damaging effects of endotoxin – reducing insulin resistance and the symptoms of diabetes.

And glycine directly protects against the cancer promoting effects of the polyunsaturated fats.

“…glycine completely prevented the increase in hepatocyte proliferation caused by corn oil.”

Glycine also helps recovery from stroke, and reduces symptoms of MS, schizophrenia and arthritis.

“We conclude that glycine was associated with reduced symptoms with promising effect sizes in two pilot studies and a possibility of improvement in cognitive function.”

Dietary glycine – sometimes consumed from a gelatinous beef broth – also protects against all types of inflammatory bowel disease.

“A diet containing glycine ameliorated diarrhea and body weight loss…and improved both macroscopic and histologic scores of colitis significantly.”

Consuming sufficient sugar – in the form of sweet ripe fruits or juices, honey, milk and simple white sugar – and balancing your protein intake with gelatin – or supplemental glycine – will help to protect against the multi faceted disease and inflammation promoting effects of the stress hormones such as cortisol, serotonin, prolactin, growth hormone and more.

“Glycine appears to exert several protective effects, including antiinflammatory, immunomodulatory and direct cytoprotective actions.”

Restricting intake of foods high in tryptophan, cysteine and methionine – whilst also increasing intake of glycine – is one useful approach to protection against disease and aging in general.

“Dietary methionine (Met) restriction (MR) extends lifespan in rodents by 30–40%…We propose that more efficient Met clearance…with GS [glycine supplementation] could be reducing chronic Met toxicity…”

Have you tried using gelatin as part of your daily protein?

See more here

Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge.

L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent.

Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats.

Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms

Dietary glycine prevents chemical-induced experimental colitis in the rat.

Dietary glycine inhibits the growth of B16 melanoma tumors in mice.

Glycine as a potent anti-angiogenic nutrient for tumor growth.

Effects of orally administered glycine on myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle in chicks

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats.

Effects of some putative amino acid neurotransmitters on the stimulated TSH secretion in male rats.

Scallop protein with endogenous high taurine and glycine content prevents high-fat, high-sucrose-induced obesity and improves plasma lipid profile in male C57BL/6J mice.

Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats

Glycine treatment of the risk syndrome for psychosis: report of two pilot studies.

Arginine Deprivation as a Targeted Therapy for Cancer

Arginine deprivation and autophagic cell death in cancer


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