Aspirin! Because You May Not Need To F%#k Cancer After All.
There are lots of reasons to be angry about cancer, but when you find out just how effective aspirin is, as both a preventative measure and treatment (even cure), you might move from anger and suffering, skipping past worry and sadness, straight on up to murderous intent.
“Observational studies show that regular use of aspirin reduces the long-term risk of several cancers and the risk of distant metastasis. Results of methodologically rigorous studies are consistent with those obtained from randomised controlled trials…”
“We find that ASA [aspirin] not only prevents breast tumor cell growth…and tumor growth…but also significantly reduces the self-renewal capacity and growth of breast tumor-initiating cells/breast cancer stem cells…and delays the formation of a palpable tumor.”
“The goal in this study was to investigate the antitumor effect of aspirin in glioblastoma cells and the molecular mechanism involved in its antineoplastic activities…results suggest that aspirin is a potent antitumor agent, and that it exerts its antineoplastic action by inhibition of the β-catenin/TCF signaling pathway in glioma cells.”
Of course aspirin isn’t only effective in relation to cancer, because that isn’t how biology and metabolism works, and – contrary to the modern mainstream medical myth – cancer is actually a biological, metabolic issue.
“…aspirin…an anti-inflammatory agent…is currently used extensively as a cardioprotective and antithrombotic agent…regular use of aspirin is associated with a reduced risk for colorectal, oesophageal, breast, lung, prostate, liver and skin cancers…both constituent groups of aspirin…the acetyl and salicylate moieties have distinct targets that…contribute to its anticancer effects.”
“…aspirin inhibits protein aggregation and the ensuing toxicity of aggregates through its acetyl-donating activity. This mechanism may contribute to the neuro-protective, cardio-protective, and life-prolonging effects of aspirin.”
In fact aspirin can be helpful with almost any physiological problem arising out of exposure (both internally and externally) to chronic and acute stress, and stress is a fundamental driver of cancer and many other inflammatory diseases.
“…aspirin…appears to reduce staphylococcal virulence…aspirin may have the potential to be an effective adjunctive agent in the treatment of serious hospital- or community-acquired S. aureus infections.”
“Aspirin can reduce oxidative stress and protect against oxidative damage….evidence suggests…beneficial effects of aspirin…in mood disorders and schizophrenia, and…data suggests…aspirin is associated with a reduced risk of AD [Alzheimer’s].”
“Aspirin therapy, in doses commonly employed in practice, has an excellent safety profile in rheumatoid arthritis…Aspirin therapy merits reconsideration as adjunctive therapy for the management of rheumatoid arthritis.”
Aspirin helps to protect against stress by improving the function of metabolism in general. One way it does this, is by protecting against the escalation of inflammation (and numerous other symptoms) arising as a result of interference with thyroid energy systems.
Suppression of thyroid energy metabolism promotes (and is promoted by) inflammation. Inflammation and thyroid dysfunction are interconnected with issues relating to proper cellular and mitochondrial performance, interference with enzyme activity, increased use of fat (and decreased use of sugar) for fuel, combined with more exposure to free fatty acids, lipid peroxidation and oxidative stress. Aspirin has beneficial effects in relation to all of these things, and all of these things have been shown to be involved in the development of cancer and metabolic illness in general.
“Epidemiologic and clinical studies indicate that inflammation is correlated with an increased risk of recurrence in breast cancer patients…multiple meta-analyses showed that patients with cardiovascular diseases treated with…aspirin, have reduced cancer risk.”
“Our observations confirm that low-T3 levels are commonly found in ESRD [end-stage renal disease] patients on PD [Peritoneal dialysis] and show that this alteration is linked to low-grade inflammation and death in this population.”
“Neutrophils have a fundamental role in inflammatory responses…neutrophils specifically support metastatic initiation…neutrophil-derived leukotrienes aid the colonization of distant tissue by selectively expanding the sub-pool of cancer cells that retain high tumorigenic potential…inhibition of the leukotriene-generating enzyme arachidonate 5-lipoxygenase…abrogates neutrophil pro-metastatic activity and consequently reduces metastasis.”
“…we provide new molecular mechanisms underlying the pleiotropic response to ASA by demonstrating that this NSAID promotes the formation of endogenous anti-inflammatory compounds…and modulates 5-LO [5-lipoxygenase] activity…decreasing 5-LO activity in macrophages…a central role in the control of inflammation…”
This is a good way to understand some of the reasons why aspirin is beneficial in relation to protection from heart disease and stroke, but also depression, diabetes and insulin resistance. And then there is its use for the treatment of Alzheimer’s or neuroprotection in general. Not to mention it’s effectiveness in relation to hypertension, pregnancy and fertility issues, and an almost endless list of other symptoms or conditions.
There is a huge amount of quality scientific experimentation (available for pretty much anybody to look at), which demonstrates the many powerful ways aspirin can protect against disease – including many regarding cancer – and not just simply as a preventative measure.
“We conducted a prospective study from 1992 through 1999 among 28 283 postmenopausal women…There was a trend of decreasing risk of pancreatic cancer incidence with increasing frequency of aspirin use per week.”
Scientists (working for governments and pharmaceutical companies) all over the world have been attempting to use the physiological effects of aspirin as a model to assist in finding a cure for cancer. But is that really all that they are looking for?
“…a novel, gastrointestinal-safe phosphatidylcholine (PC)-associated aspirin, PL2200 Aspirin, possesses the same or more pronounced actions versus unmodified aspirin with regard to antiplatelet effects…and chemoprevention.”
There seems to be an ongoing race to develop new products modeled on aspirin (which would provide similar positive results in relation to cancer), but different enough to be able to be patented, as a means to making oodles and oodles of dinero.
“…we report a significant reduction in HNC [head and neck cancer] risk with aspirin use, with the strongest protective effect for laryngeal cancers. No association was observed between HNC and ibuprofen use.”
Unfortunately however, there is no guarantee that whatever is produced will match the manner in which aspirin (tried and tested for many decades) works to safely provide physiological protection, including chemotherapeutic benefit. But it’s hard to make the big money out of something so widely and cheaply available, even if it does work better than more recent products.
Many of the substances which are known to rise in times of stress – cortisol, serotonin, estrogen, nitric oxide, lactate, growth hormone, prolactin, the polyunsaturated free fatty acids and prostaglandins – do so because of the ways that stress interferes with metabolic function.
The stress substances are involved in the promotion of inflammatory conditions, and are known to rise under circumstances where thyroid energy metabolism is suppressed. Aspirin has been demonstrated to be able to reduce exposure to the disease promoting stress materials.
“…results suggest that postmenopausal women who regularly use aspirin…may have lower estrogen levels…We observed significant inverse associations between total NSAID use and concentrations of estradiol and free estradiol…analgesics that decrease aromatase activity via suppression of COX expression and prostaglandin synthesis also may decrease estrogen concentrations”
“The inhibition of iNOS expression by aspirin was further associated with a reduced ability…to produce TNF-alpha. This study could provide new mechanisms of action for aspirin in the treatment of the inflammation-related…diseases.”
“The results clearly show that…ASA ingestion significantly blunted the increased serum ACTH, beta-endorphin, cortisol, and GH [growth hormone] levels…and was associated with reduced cortisol concentration…[and] a significantly reduced total PRL [prolactin] response to stress condition[s]…”
“Aspirin (ASA), a platelet aggregation inhibitor, inhibits 5-HT [serotonin] release from platelets…Plasma 5-HT was measured by high-performance liquid chromatography…The effects of ASA was associated with a reduction of 5-HT.”
A lack of energy supply (in combination with continuous exposure to excessive levels of the stress substances and promoters of inflammation) has been demonstrated to be a significant driving force behind the onset and development of cancer. Sugar is an optimal energy source and a fundamental anti-stress substance.
“We show that the targeted therapy with iNOS inhibitors is able to inhibit not only tumor cell proliferation but also…self-renewal and migration, reducing tumor growth, tumor initiation, and the number of lung metastases…”
“17-β-estradiol can act as a carcinogenic agent without the need of the ERα…The knowledge that breast cancer in women is associated with prolonged exposure to high levels of estrogens gives relevance to this model of estrogen induced carcinogenesis.”
“Dietary soy isoflavones increase metastasis to lungs in a model of breast cancer and a recent study reported significantly increased cell proliferation in breast cancer patients who used soy supplementation. The soy isoflavone daidzein is a major food-derived phytoestrogen that is structurally similar to estrogen.”
Even when enough sugar is being provided (and unused supplies are available), ongoing exposure to inflammation and the substances of stress, are important factors which can interfere with the proper utilization of available sugar for energy, and this can make a return to normal function difficult. Aspirin can help protect against the things that interfere with the use of sugar for fuel and stress reduction.
“Insulin-stimulated whole-body glucose uptake was decreased by 37% with the lipid infusion…Salicylate pretreatment prevented these decreases…Salicylate pretreatment also prevented the lipid-induced decreases in insulin-stimulated skeletal muscle glucose metabolism…salicylate pretreatment prevents lipid-induced skeletal muscle insulin resistance…these results provide important new insights into the mechanism of fat-induced insulin resistance…and suggest a potentially novel class of therapeutic agents for type 2 diabetes.”
“…high dose aspirin treatment improved both fasting and postprandial hyperglycemia in patients with type 2 diabetes, an effect that could be attributed to decreased basal rates of hepatic glucose production, enhanced peripheral insulin sensitivity, and decreased insulin clearance.”
“In fasting conditions, the lipolytic activity of adipocytes is stimulated by catecholamines…aspirin has been reported to reduce catecholamine-stimulated lipolysis…In addition…aspirin reduces release of FA [fatty acids] from adipose tissue directly via inhibition of TNFα-induced lipolysis…”
It’s safe to say that aspirin helps to protect against inflammation and disease, by improving the function of metabolic energy systems in a variety of ways which help reduce stress and interference with cellular performance, often the result of excessive exposure to cancer promoting substances such as cortisol, estrogen, nitric oxide and the breakdown products of polyunsaturated fats.
“Since FAs [fatty acids] are essential for cancer cell proliferation, limiting their availability could provide a therapeutic strategy. From the perspective of lipid metabolism, limiting FA availability could be achieved in several ways…”
“Abnormal lipid metabolism is a hallmark of tumorigenesis. Hence, the alterations of metabolism enhance the development of hepatocellular carcinoma (HCC)…Therapeutically, aspirin is potentially available for HCC through controlling abnormal lipid metabolism.”
“…stress…caused brain expression of iNOS, an increase in plasma glutamate and brain TNF-alpha, induction of oxidative indicators in brain and a fall in brain ATP levels….aspirin…inhibited all these effects caused by stress…”
“Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway are angiogenic, inducing cancer tumor growth.”
“Aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes…Aspirin decreased lipid peroxidation…we demonstrated the potential effects of aspirin on biochemical and neurobehavioral recovery…”
You can see why aspirin is threatening. For starters, if enough people were convinced of its protective ability in relation to cancer, that could damage the popular myth which states that ‘modern science’ is always moving forward in the direction of greater understanding of the causes and treatments of serious illness.
But just think about what’s been known for decades about the benefits of aspirin, and consider the fact that the dangers of aspirin have been shown in many cases to be overblown. There’s no end to the amount of research that can be done, but it won’t change the fact that aspirin already works right now. So what are they waiting for?
“…aspirin suppressed prostate cancer cell invasion by reducing MMP-9 activity and uPA expression through decreasing of IKK-β-mediated NF-κB activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.”
“…salicylate…exhibit anti-tumor activity against…leukemia…We…tested…other NSAIDs, including acetaminophen and indomethacin…but did not detect any inhibitory activity…salicylate may be useful for treating inflammation, diabetes, neurodegenerative disease, and other pathologies…”
Perhaps another fear is that acknowledging the truth about how aspirin works might eventually promote alternative (biologically valid) explanations for cancer development, and that this will cause a flow-on effect, unmasking ineffective and harmful products or treatment methodologies across the board.
I’m not a doctor or health practitioner or a scientist of any sort, and I’m not here to give advice. Read the arguments. Have a look though the science.
There are however, those who believe that it makes more sense to look at cancer (rather than simply as some kind of genetic disease) as a reasonably normal reaction of cells – doing the best they can to keep you alive and functioning – after a certain amount of time being subjected to ‘unnatural’ (or excessively stressful) conditions.
At moments like this it seems more appropriate – rather than saying ‘f%#k cancer’ – to say ‘f&$k the cancer industry’, and all the related organizations and industries which have helped muddy the waters surrounding the true causes of (and really effective approaches to protecting against or even treating) cancer, in the name of greed and power.
“The present meta-analysis, which involves approximately 300,000 participants from 16 studies, has confirmed the antineoplastic effects of NSAIDs in multi-cancer metastasis…aspirin was the most predominant NSAID given to patients.”
You see, if everything can cause cancer, and nothing can cure cancer, it becomes easier to get away with selling things that actually cause cancer, and things that really can’t cure cancer, whilst at the same time avoiding competition from the things that actually don’t cause cancer and things that really do cure cancer. Was that clear?
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Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor α-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4