Endotoxication

If you're going to be a germophobe, you might as well worry about the bugs that play arguably the most important role in messing with your immune system and metabolism. And don't forget to look at how they arise on the inside, rather than wasting all your efforts trying to stop things landing on you from the outside.

Call me crazy, but I do believe it might be a little too optimistic to think that you can control your exposure to a whole lot of microscopic critters floating around in the air, not to mention the idea that you can somehow trace all the supposed links between people they landed on, and then safely lock them away.

But don’t worry, there are better ways. One thing you can do, is deal with the factors known to make you susceptible to the development of a wide variety of symptoms and illnesses, including those illnesses blamed on bugs attacking from the outside. A good way to do this, is to reduce exposure to bacterial endotoxin, in the place you have the most control over it, where it’s produced on the inside.

Many people have never heard of endotoxin, let alone being aware of science examining the biological impact exposure to endotoxin has on immune system function and metabolism. Few people ever hear how many different kinds of symptoms and inflammatory conditions are the result of excess endotoxin. You might think you caught something, but it is possible what is happening is not what you think.

A critical review of human endotoxin administration as an experimental paradigm of depression; Neurosci Biobehav Rev. 2010 Jan; 34(1): 130–143.

In humans, endotoxin…cause flu-like symptoms (fever, chills, myalgia, headache, nausea) and increases in blood TNF and IL-6 levels similar to what is seen in sepsis…

Endotoxin – or Lipopolysaccharide (LPS) – is produced by bacteria found in the intestines, and there are a number of ways to explain why someone might have a problem with endotoxin, that has nothing to do with a bug landing on them.

It’s well known that inflammation is central to the development of metabolic illness, and endotoxin interacts with many biochemical substances involved in the development of inflammation and related issues.

The TLR proteins are activated by endotoxin, and they promote the release of proinflammatory cytokines (cell signaling proteins), including TNF-alpha, interleukin (IL)-1β, and IL-6. Endotoxin can also directly cause inflammation.

Once you have a better understanding of the factors that interact in the development of endotoxin problems, it’s much easier to see which things (that aren’t just randomly landing on you) might be harming you, and also to discover powerful weapons available that can protect you.

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?; Cytokine Growth Factor Rev. 2020 Sep 21.

The severe form of COVID-19 is marked by an abnormal and exacerbated immunological host response favoring to a poor outcome in a significant number of patients, especially those with obesity, diabetes, hypertension, and atherosclerosis. The chronic inflammatory process found in these cardiometabolic comorbidities is marked by the overexpression of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumoral necrosis factor-alpha (TNF-α), which are products of the Toll-Like receptors 4 (TLR4) pathway.

Stress and interference with thyroid energy metabolism promotes digestive dysfunction and intestinal bacterial issues, as well as impeding gut barrier function, which then allows for greater amounts of bacterial endotoxin to pass through into the main system, overloading the liver and harming every organ system. An overloaded liver harms overall function in a variety of different ways causing a downward spiral of problems.

This type of scenario is circular and involves increasing systemic circulation of a number of inflammatory stress substances other than endotoxin, including serotonin, cortisol, nitric oxide, and the polyunsaturated free fatty acids, all of which promote metabolic illness, and a worsening of the severity of symptoms, including those presumed to be the result of some kind of viral infection.

The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection; Intensive Care Med Exp. 2018 Dec; 6: 15. 

An LPS challenge in the acute phase of influenza infection results in an enhanced pulmonary pro-inflammatory innate immune response. These data increases our insight concerning viral-bacterial interplay. Combined with previous findings, it appears that this enhanced pro-inflammatory response does not lead to protection against secondary infections but rather causes immunopathology leading to damage, and thereby to organ failure.

Any time you feel like you are coming down with something that you caught somewhere, the symptoms can probably be explained by endotoxin and the other inflammatory metabolism inhibiting substances.

There’s a long list of things that can potentially allow the bugs inside you and their byproducts, to proliferate and to get into your bloodstream and pass through to all of your organ systems. They include dietary issues like the PUFAs and digestion irritating fibers and gums and other chemicals, sugar avoidance, insufficient protein and other deficiencies, chronic emotional stress, excessive exercise, starvation and fasting, lack of sunlight, many other things that you don’t catch.

Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?; mBio. 2020 Jul 23;11(4):e01723-20. 
There is high mortality in coronavirus disease 2019 (COVID-19)-infected individuals with chronic inflammatory diseases, like obesity, diabetes, and hypertension…leakage of proinflammatory endotoxin from the gut is hypothesized to add to the TLR4-mediated inflammation that the host develops in response to the viral infection…individuals with chronic inflammatory diseases should consider changing their diets before they are infected to attenuate the development of the most severe symptoms…

I’m not a doctor or health professional and this is not advice, but before you jump to any conclusions and start spraying everything around you, maybe stop for a second and think about what is in the spray, and what happens to you when you ingest it in combination with all the other harmful, toxic, and poisonous things that have accumulated in your system, many of which are cheap and easy to avoid.

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